中法核工程与技术学院核声论坛（总第202期）

Abstract：

Along with the approval and availability of new radiotheranostic agents, the urge of personalized internal dosimetry for targeted radionuclide therapy (TRT) is being recognized worldwide. In order to maximize the tumor dose,keeping thepotential toxicity in critical organs under a safety leveland monitor the treatment effects,the conventional fixed or mass-based injection activity regime is obviously deficit.Patient-specifictreatment planning based on patients’ own kinetics data is desirable,with reference to the common practice of external beam radiation therapy. Quantitative3D imaging methods, especially SPECT/CT and PET/CT, can provide the spatial distribution of TRT theranostic tracers on a voxel level with improved quantitative accuracy. Following quantitative imaging, the use of a streamlined 3D dosimetric software with functions of volume-of-interest segmentation, image registration, time-activity-curve fitting and dose conversion is essential for successful clinical dosimetry practice. Here we present an overview and share our current research experience of two contemporary radiotheranostic applications, i.e., Y-90 microsphere for liver cancer and Lu-177 PSMA therapy for prostate cancer. A self-developed comprehensive and 1-stop internal dosimetry software, BIGDOSE, will also be introduced.

About the speaker：

Prof. Greta Seng Peng MOK is a Professor in the Department of Electrical and Computer Engineering, Faculty of Science and Technology at the University of Macau, with joint affiliations at the Center for Cognitive and Brain Sciences and the MOE Frontiers Science Center for Precision Oncology. She earned her Ph.D. in Medical Imaging Physics from Johns Hopkins University, USA, and her B.S. in Biomedical Imaging and Radiological Sciences from Yang-Ming University, Taiwan. Her research encompasses medical imaging technologies including SPECT, PET, multi-modality imaging (PET/SPECT/CT/MRI), internal dosimetry, molecular imaging, and AI in medical imaging. Prof. Mok serves as Associate Editor for EJNMMI Physics and Medical Physics, and is a member of the Editorial Board members of EJNMMI, Quantitative Imaging in Medicine and Surgery (QIMS) and Nuclear Medicine and Molecular Imaging (NMMI). She published >110 SCI papers and is the principle investigator of >20 funded research projects, including the 2020-2022 Excellent Young Scientists Fund (Hong Kong and Macau) from Natural Science Foundation of China.She is the Founding and Current President of the Macao Society of Nuclear Medicine and Molecular Imaging and a Senior Member of IEEE.